United States securities and exchange commission logo February 8, 2023 Hayden Brown President and Chief Executive Officer Upwork Inc. 475 Brannan Street, Suite 430 San Francisco, California 94107 Re: Upwork Inc. Form 10-K for the Year Ended December 31, 2021 Filed February 15, 2022 File No. 001-38678 Dear Hayden Brown: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Technology cc: Brian Levey