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  <xs:element id="upwk_StockIssuedDuringPeriodValueStockOptionsAndWarrantExercised" abstract="false" name="StockIssuedDuringPeriodValueStockOptionsAndWarrantExercised" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_StockRepurchasedDuringPeriodIncludingExciseTaxShares" abstract="false" name="StockRepurchasedDuringPeriodIncludingExciseTaxShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="upwk_StockRepurchasedDuringPeriodIncludingExciseTaxValue" abstract="false" name="StockRepurchasedDuringPeriodIncludingExciseTaxValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_IncreaseDecreaseInCommonStockWarrant" abstract="false" name="IncreaseDecreaseInCommonStockWarrant" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_IncreaseDecreaseOperatingLeaseLiability" abstract="false" name="IncreaseDecreaseOperatingLeaseLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_ChangesInEscrowFundsPayableNet" abstract="false" name="ChangesInEscrowFundsPayableNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_ProceedsFromExercisesOfStockOptionsAndCommonStockWarrants" abstract="false" name="ProceedsFromExercisesOfStockOptionsAndCommonStockWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_InternalUseSoftwareAndPlatformDevelopmentCostsIncurredButNotPaid" abstract="false" name="InternalUseSoftwareAndPlatformDevelopmentCostsIncurredButNotPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_MarketplaceMember" abstract="true" name="MarketplaceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_EnterpriseMember" abstract="true" name="EnterpriseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_RestOfWorldMember" abstract="true" name="RestOfWorldMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_CommercialDepositsMember" abstract="true" name="CommercialDepositsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_ForeignGovernmentAgenciesDebtSecuritiesMember" abstract="true" name="ForeignGovernmentAgenciesDebtSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_MarketableSecuritiesCurrentMember" abstract="true" name="MarketableSecuritiesCurrentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_FundsHeldInEscrowIncludingFundsInTransit" abstract="false" name="FundsHeldInEscrowIncludingFundsInTransit" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_A2024ShareRepurchaseAuthorizationMember" abstract="true" name="A2024ShareRepurchaseAuthorizationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_A2023ShareRepurchaseAuthorizationMember" abstract="true" name="A2023ShareRepurchaseAuthorizationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_AccruedVendorExpensesCurrent" abstract="false" name="AccruedVendorExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_AccruedPaymentProcessingFeesCurrent" abstract="false" name="AccruedPaymentProcessingFeesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_AccruedTalentCostsCurrent" abstract="false" name="AccruedTalentCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_BubtyB.V.Member" abstract="true" name="BubtyB.V.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_ConvertibleSeniorNotesMember" abstract="true" name="ConvertibleSeniorNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_DebtInstrumentConvertibleBusinessPeriod" abstract="false" name="DebtInstrumentConvertibleBusinessPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="upwk_DebtInstrumentConvertibleMeasurementPeriod" abstract="false" name="DebtInstrumentConvertibleMeasurementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="upwk_DebtInstrumentConvertibleMeasurementPeriodPercentage" abstract="false" name="DebtInstrumentConvertibleMeasurementPeriodPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="upwk_OptionIndexedToIssuersEquityStrikePricePremiumOverSharePricePercentage" abstract="false" name="OptionIndexedToIssuersEquityStrikePricePremiumOverSharePricePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="upwk_RestrictedStockUnitsRSUsAndPerformanceSharesMember" abstract="true" name="RestrictedStockUnitsRSUsAndPerformanceSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_ExpensesRelatedToTidesFoundationWarrantMember" abstract="true" name="ExpensesRelatedToTidesFoundationWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_ExpensesRelatedToBusinessCombinationMember" abstract="true" name="ExpensesRelatedToBusinessCombinationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_AscenIncMember" abstract="true" name="AscenIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_OlivierMarieMember" abstract="true" name="OlivierMarieMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_DavidT.BottomsMember" abstract="true" name="DavidT.BottomsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_SharesIssuableUponVestingReleasedPriorToAdoptionDateRSUsMember" abstract="true" name="SharesIssuableUponVestingReleasedPriorToAdoptionDateRSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_SharesIssuableUponVestingReleasedPriorToRetirementDateRSUsMember" abstract="true" name="SharesIssuableUponVestingReleasedPriorToRetirementDateRSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_SharesIssuableUponVestingReleasedOnOrPriorToExpirationDateRSUsMember" abstract="true" name="SharesIssuableUponVestingReleasedOnOrPriorToExpirationDateRSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_SharesIssuableUponVestingReleasedOnOrPriorToExpirationDatePSUsMember" abstract="true" name="SharesIssuableUponVestingReleasedOnOrPriorToExpirationDatePSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
