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  <xs:element id="upwk_ManagedServicesMember" abstract="true" name="ManagedServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_ChangesInEscrowFundsPayable" abstract="false" name="ChangesInEscrowFundsPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_AccruedIndirectTaxesCurrent" abstract="false" name="AccruedIndirectTaxesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_ProvisionForTransactionLosses" abstract="false" name="ProvisionForTransactionLosses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_LettersOfCreditHeld" abstract="false" name="LettersOfCreditHeld" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="upwk_YankeeBondMember" abstract="true" name="YankeeBondMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_SupranationalBondsMember" abstract="true" name="SupranationalBondsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_EscrowFundsPayable" abstract="false" name="EscrowFundsPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_AccruedCompensationAndRelatedBenefitsCurrent" abstract="false" name="AccruedCompensationAndRelatedBenefitsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_OptionIndexedToIssuersEquityStrikePricePremiumOverSharePricePercentage" abstract="false" name="OptionIndexedToIssuersEquityStrikePricePremiumOverSharePricePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="upwk_AccruedPaymentProcessingFeesCurrent" abstract="false" name="AccruedPaymentProcessingFeesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_ProceedsFromExercisesOfStockOptionsAndCommonStockWarrant" abstract="false" name="ProceedsFromExercisesOfStockOptionsAndCommonStockWarrant" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_MarketplaceEnterpriseMember" abstract="true" name="MarketplaceEnterpriseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_AccruedExpensesAndOtherCurrentLiabilities" abstract="false" name="AccruedExpensesAndOtherCurrentLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
