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  <xs:element id="upwk_FundsHeldInEscrowAndEscrowFundsPayableNumberOfMoneyTransmitters" abstract="false" name="FundsHeldInEscrowAndEscrowFundsPayableNumberOfMoneyTransmitters" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="upwk_OfficeFloorMember" abstract="true" name="OfficeFloorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_OperatingLeaseAssetMember" abstract="true" name="OperatingLeaseAssetMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_FirstTermLoanMember" abstract="true" name="FirstTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_EscrowFundsPayable" abstract="false" name="EscrowFundsPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="upwk_YankeeBondMember" abstract="true" name="YankeeBondMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_DebtInstrumentConvertibleMeasurementPeriodPercentage" abstract="false" name="DebtInstrumentConvertibleMeasurementPeriodPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="upwk_RestrictedStockUnitsRSUsAndPreferredStockUnitsPSUsMember" abstract="true" name="RestrictedStockUnitsRSUsAndPreferredStockUnitsPSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_MajorCustomer1Member" abstract="true" name="MajorCustomer1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_TidesFoundationMember" abstract="true" name="TidesFoundationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_SanFranciscoCaliforniaMember" abstract="true" name="SanFranciscoCaliforniaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="upwk_ShareBasedPaymentArrangementTrancheFourMember" abstract="true" name="ShareBasedPaymentArrangementTrancheFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
